Ankylosing Spondylitis - Biological Therapies Open New Therapeutic Option
Some diseases such as psoriasis the Spondilitis rheumatoid arthritis or Ankylosing spondylitis arise because "in the body produces an immune response that is abnormal and exaggerated and that releases certain substances that are responsible for the inflammatory process. With biological therapies act on those substances that cause inflammation or infection"
How a Biological treatment
These are drugs (so called modifiers) clinicians and they have in common seeking to or recombine effectively blocked the action of Tumor Necrosis Factor (its acronym in English are TNF).
Tumor Necrosis Factor (TNF):
It is one of the elements involved in maintaining of swollen in patients with AS and is produced by inflammatory cells stimulates coagulation and recruit other leukocytes (white cells) to the site of inflammation. TNF which is one of the cytokines (are diverse and potent chemical messengers secreted by immune-system cells and are the principle tool T cells) immune system's most important is the messenger of a protein (metalloproteinase) is guilty of initiating and magnify the response of patients suffer from inflammation of AS.
TNF is formed in the very immune system cells especially macrophages and T cells when it detects the presence of a pathogen (infectious agent).
The popular potent stimulus to produce TNF is the LPS (found mainly in the cell wall of gram-negative bacteria and other microorganisms).
TNF production is important to protect the body infection but the problem arises when the body creates excessive amounts of TNF being passed by the blood to other parts of the body and its protective role becomes aggressive.
TNF is shaped by specific cells macrophages and synoviocytes (for joints) which are cells of the synovial lining. In inflammation of AS the level den be present both in the joint fluid as in serum.